Refrigerant Knowledge Center

What Is R407C Refrigerant? Properties, Uses and Safety

R407C is an A1 zeotropic HFC blend used in air conditioning, heat pumps and some refrigeration applications, with operating characteristics close to R22 in selected conversions but meaningful temperature glide.

DesignationR407C
FamilyHFC blend
Safety ClassA1
GWP1774
ODP0
Lifecyclephase-down

What Is R407C?

R407C is an A1 zeotropic HFC blend used in air conditioning, heat pumps and some refrigeration applications, with operating characteristics close to R22 in selected conversions but meaningful temperature glide.

R407C is classified as zeotropic blend in the HFC blend family. Its composition is 23% R32 / 25% R125 / 52% R134a by mass. Refrigerant choice is never based on designation alone: capacity, pressure, lubricant, controls, heat-exchanger behavior, safety standards and local rules all matter.

R407C Technical Properties

General reference values for comparison; a current product specification and applicable regulatory basis govern a transaction.

Refrigerant designation R407C
Chemical family HFC blend
Composition 23% R32 / 25% R125 / 52% R134a by mass
Blend type zeotropic blend
ASHRAE safety class A1
100-year GWP 1774 (manufacturer-reported 100-year GWP)
Ozone depletion potential 0
Normal boiling reference -43.6 (bubble point; glide applies) °C
GWP basis matters: different IPCC assessment reports can assign different values to the same refrigerant. Use the value specified by the regulation or procurement standard that applies to your project.

Common R407C Applications

Typical references include air conditioning, heat pumps, and medium-temperature refrigeration.

Air Conditioning

Use depends on equipment design, operating envelope and applicable local requirements.

Heat Pumps

Use depends on equipment design, operating envelope and applicable local requirements.

Medium-temperature Refrigeration

Use depends on equipment design, operating envelope and applicable local requirements.

Advantages and Limitations

Selection advantages

  • Established refrigerant designation with published reference data.
  • Application history in air conditioning.
  • ODP reference of 0.

Important limitations

  • A1 safety controls must be applied.
  • GWP and lifecycle status can affect long-term selection.
  • No refrigerant should be treated as a universal drop-in.

Environmental Impact and Regulation

Its HFC content and GWP may trigger market-specific restrictions or phase-down pressure even where servicing remains permitted.

R407C has an ODP reference of 0 and a stated GWP of 1774 using manufacturer-reported 100-year GWP. Regulations commonly distinguish between manufacturing or import, new equipment, servicing, recovered material and individual end uses.

Verification date: July 2026. Confirm current rules with the competent authority for the destination and equipment category before making a compliance decision.

Safety, Handling and Storage

Charge as liquid and account for temperature glide when setting superheat, subcooling and heat-exchanger calculations; do not top up a fractionated charge blindly.

The A1 classification describes toxicity and flammability groupings; it does not by itself approve a refrigerant for a particular system. Review the current safety data sheet, cylinder label, transport classification, equipment manual and local code.

R407C Alternatives and Comparisons

Candidate alternatives must be evaluated as system choices, not simple chemical substitutions.

R32

HFC; A2L safety class; GWP 675 on the stated IPCC AR4 100-year basis.

Read the R32 guide

R454B

HFO/HFC blend; A2L safety class; GWP 467 on the stated IPCC AR5 100-year, manufacturer-reported basis.

Read the R454B guide

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Review packaging, documentation and inquiry requirements for R407C.

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R407C Frequently Asked Questions

What is R407C made of?

23% R32 / 25% R125 / 52% R134a by mass; it is categorized as zeotropic blend.

What is the safety class of R407C?

The published classification used in this guide is A1. Equipment approval and local safety rules still apply.

What is the GWP of R407C?

The reference here is 1774 on the manufacturer-reported 100-year GWP basis. Other assessment bases may show a different number.

Can R407C replace another refrigerant directly?

No universal drop-in claim is made. Compatibility and conversion requirements must be confirmed for the exact equipment.

Where is R407C commonly used?

Typical applications include air conditioning, heat pumps, and medium-temperature refrigeration, subject to equipment design and local approval.

References and Technical Sources

Source data is summarized for general education. Always use current official documents, standards and supplier-specific safety and technical data for engineering or compliance decisions.

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